UPMC Hillman Cancer Center

Lung Cancer SPORE


Project 1

Siegfried JM, Gubish CT, Rothstein ME, Henry C, Stabile LP. Combining the multitargeted tyrosine kinase inhibitor vandetanib with the antiestrogen fulvestrant enhances its antitumor effect in non-small cell lung cancer. J Thorac Oncol. 2012 Mar;7(3):485-95. PMCID:PNC3288546

Project 2

Srinivasan M, Parwani AV, Hershberger PA, Lenzner DE, Weissfeld JL. Vitamin D Receptor Expression and Overall Survival in Non-Small Cell Lung Cancer: Prognostic and Therapeutic Implications. J Steroid Biochem Mol Biol 2011, 123(1-2):30-6. Epub 2010 Oct 16. PMCID:PNC3010457

Zhang Q, Kanterewicz B, Buch S, Petkovich M, Parise R, Beumer J, Lin Y, Diergaarde B, Hershberger PA. CYP24 inhibition preserves 1,25-dihydroxyvitamin D3 anti-proliferative signaling in lung cancer cells. Mol Cell Endocrinol. 2012 May 15; 355(1):153-61. Epub 2012 Feb 22. PMCID:PMC3312998

Project 3

Zeng X, Hood BL, Zhao T, Conrads TP, Sun M, Gopalakrishnan V, Grover H, Weissfeld JL, Wilson DO, Siegfried JM, Bigbee WL. (2011) Lung cancer serum biomarker discovery using label free LC-MS/MS. J Thoracic Oncol 6: 725-734. PMCID: PMC3104087

Bigbee WL, Gopalakrishnan V, Weissfeld JL, Wilson DO, Dacic S, Lokshin AE, Siegfried JM. (2012) A multiplexed serum biomarker immunoassay panel discriminates clinical lung cancer patients from high-risk individuals found to be cancer-free by CT screening. J Thoracic Oncol 7: 698-708. PMCID:PMC3308353. Also listed as a publication in the Biostatistics/Bioinformatics Core

Buch SC, Diergaarde B, Nukui T, Day RS, Siegfried JM, Romkes M, Weissfeld JL. (2011) Genetic variability in DNA repair and cell cycle control pathway genes and risk of smoking-related lung cancer. Mol Carcinog. 2011 Oct 4. doi: 10.1002/mc.20858. [Epub ahead of print] PMCID: PMC3289753.

Project 4

Alyssa D. Gregory and A. McGarry Houghton. Tumor-associated neutrophils: new targets for cancer therapy (Review), Cancer Research. 2011 71(7):2411-6 PMID:21427354

Clinical Core

Schuchert MJ, Abbas G, Awais O, Pennathur A, Nason KS, Wilson DO, Siegfried JM, Luketich JD, Landreneau RJ. Anatomic Segmentectomy for the Solitary Pulmonary Nodule and Early-Stage Lung Cancer. Ann Thorac Surg (Available online April 6, 2012) PMID: 22483652

Schuchert MJ, Souza AP, Abbas G, Pennathur A, Nason KS, Jack R, Horne ZD, Landreneau JR, Santana M, Wilson DO, Luketich JD, Landreneau RJ. Extended Chamberlain Mini-Thoracotomy: A Safe and Versatile Approach for the Difficult Lung Resections. Ann Thorac Surg. 2012;93:1641-6. PMID: 22464035

Schuchert MJ, Awais O, Abbas G, Horne ZD, Nason KS, Pennathur A, Souza AP, Siegfried JM, Wilson DO, Luketich JD, Landreneau RJ. Influence of Age and IB Status Following Resection of Node-Negative Non-Small Cell Lung Cancer. Ann Thorac Surg. 93(3):929-36, 2012 Mar. PMID: 22364984

Wilson DO, Ryan A, Fuhrman C, Schuchert M, Shapiro S, Siegfried JM, Weissfeld J. Doubling times and CT screen-detected lung cancers in the Pittsburgh Lung Screening Study. Amer J Resp Crit Care Med. 185(1):85-9, 2012 Jan 1. PMID: 21997335 (PMCID: PMC3262038)

Horne ZD, Jack R, Gray ZT, Siegfried JM, Wilson DO, Yousem S, Nason KS, Landreneau RJ, Luketich JD, Schuchert MJ. Increased Levels of Tumor-Infiltrating Lymphocytes Are Associated with Improved Recurrencefree Survival in Stage 1A Non-Small Cell Lung Cancer. J Surg Res 171(1):1-5, 2011 Nov. PMID: 21571304

Rusch VW, Hawes D, Decker PA, Martin SE, Abati A, Landreneau RJ, Patterson GA, Inculet RI, Jones DR, Malthaner RA, Cohen R, Ballman K, Putnam JB, Cote R. Occult Metastases in Lymph Nodes Predict Survival in Resectable Non-Small Cell Lung Cancer: Report of the ACOSOG Z0040 Trial. (Published Ahead of Print on October 11, 2011 as 10.1200/JCO.2011.35.2500) PMID: 21990404 (PMCID: PMC3221530)

Fernando HC, Landreneau RJ, Mandrekar SJ, Hillman SL, Nichols FC, Meyers B, Dipetrillo TA, Heron DE, Jones DR, Daley BD, Starnes SL, Hatter JE, Putnam JB. The impact of adjuvant brachytherapy with sublobar resection on pulmonary function and dyspnea in high-risk patients with operable disease: preliminary results from the American College of Surgeons Oncology Group Z4032 trial. J Thorac Cardiovasc Surg. 142(3):554- 62, 2011 Sep. PMID: 21724195 (PMCID: PMC3156868)

Kilic A, Landreneau RJ, Luketich JD, Pennathur A, Schuchert MJ. Density of Tumor-Infiltrating Lymphocytes Correlates with Disease Recurrence and Survival in Patients with Large Non-Small-Cell Lung Cancer Tumors. J Surg Res. 167(2):207-10, 2011 May PMID: 1989667

Schuchert MJ, Schumacher L, Kilic A, Close JM, Landreneau JR, Pennathur A, Awais O, Yousem SA, Wilson DO, Luketich JD, Landreneau RJ. Impact of Angiolymphatic Invasion on Outcomes Following Resection of Stage I Non-Small Cell Lung Cancer. Ann Thorac Surg. 91(4):1059-65, 2011 Apr. PMID: 21440123

Tarhini AA, Belani CP, Luketich JD, Argiris A, Ramalingam SS, Gooding W, Pennathur A, Petro D, Kane K, Liggitt D, Championsmith T, Zhang X, Epperly MW, Greenberger JS. A Phase I Study of Concurrent Chemotherapy (Paclitaxel and Carboplatin) and Thoracic Radiotherapy with Swallowed Manganese Superoxide Dismutase Plasmid Liposome Protection in Patients with Locally Advanced Stage III Non-Small- Cell Lung Cancer. Human Gene Therapy. 22(3):336-42, 2011 Mar (PMCID: PMC3057216)

Darling GE, Allen MS, Decker PA, Ballman K, Malthaner RA, Inculet RI, Jones DR, McKenna R, Landreneau R, Rusch VW, Putnam JB. Randomized Trial of Mediastinal Lymph Node Sampling Versus Complete Lymphadenectomy During Pulmonary Resection in the Patient with N0 or N1 (Less Than Hilar) Non-Small Cell Carcinoma: Results of the ACOSOG Z0030 Trial. J Thorac Cardiovasc Surg. 141(3):662-70, 2011 Mar PMID: 21335122

Bioinformatics/Biostatistics Core

Bigbee, W. L., Gopalakrishnan, V, Weissfeld J, L., Wilson, D. O., Dacic, S. Lokshin, A. E., Siegfried, J. M. A Multiplexed Serum Biomarker Immunoassay Panel Discriminates Clinical Lung Cancer Patients from High-Risk Individuals Found to be Cancer-Free by CT Screening. J Thorac Oncol. 2012 Apr;7(4):698-708. (*These authors contributed equally to the study). PMCID:PMC3308353.

Developmental Research Program

Tarhini A, Kotsakis A, Gooding W, Shuai Y, Petro D, Friedland D, Belani CP, Dacic S, Argiris A. Phase II study of everolimus (RAD001) in previously treated small cell lung cancer. Clin Cancer Res. 2010 Dec 1;16(23):5900-7. Epub 2010 Nov 2. PMID: 21045083

Carr SR, Schuchert MJ, Pennathur A, Wilson DO, Siegfried JM, Luketich JD, Landreneau RJ. Impact of Tumor Size on Outcomes Following Anatomic Lung Resection for Stage 1A Non-Small Cell Lung Cancer Based on the Current Staging System. J Thorac Cardiovasc Surg, 143 (2), 390-397, 2012, Feb. PMID: 22169444

Schuchert MJ, Kilic A, Pennathur A, Nason KS, Wilson DO, Luketich JD, Landreneau RJ. Oncologic outcomes after surgical resection of subcentimeter non-small cell lung cancer. Ann Thorac Surg. 91(6):1681-8, 2011 Jun. PMID: 21536253

Career Development Program

Egloff AM, Gaither Davis A, Shuai Y, Land S, Pilewski JM, Luketich JD, Landreneau R, Miller YE, Grandis JR, Siegfried JM. Gastrin-releasing peptide receptor expression in non-cancerous bronchial epithelia is associated with lung cancer: a case-control study. Resp Res. 13:9, 2012. PMID: 22296774 (PMCID: PMC3305653)

J. Pu, S Gu, S. Liu, S. Zhu, D. Wilson, J. M. Siegfried, and D. Gur, “CT based computerized identification and analysis of human airways: A review,” Medical Physics, Vol. 38 (5), pp. 2603-2616, 2012. [PMC3344883]

S. Gu , D. Wilson, J. Tan, and J. Pu, “Pulmonary Nodule Registration: Rigid or Non-Rigid?,” Medical Physics, Vol. 38(7), pp. 4406-4415, 2011. [PMC3145224]

S. Gu, D. Wilson, Z. Wang, W. Bigbee, J. Siegfried, J. Pu, “Identification of Pulmonary Fissures Using a Piecewise Plane Fitting Algorithm,” Computerized Medical Imaging and Graphics, accepted.

Choi, S, Toledo, LI, Fernandez-Capetilo O, Bakkenist CJ. DNA repair (Amst). 2011 10(10):1000-1001. PMID: PMCID 3189494.