UPMC Hillman Cancer Center

Lung Cancer SPORE


James G. Herman, MD, SPORE Principal Investigator

UPMC Hillman Cancer Center (Hillman) is conducting a Specialized Program of Research Excellence (SPORE) in Lung Cancer.

The overall goals of the Hillman Lung Cancer SPORE are to:

  • improve lung cancer detection
  • improve lung cancer treatment
  • identify tobacco exposed individuals at highest risk for lung cancer

The SPORE program will consist of:

  • four major translational Research Projects in lung cancer
  • three Research Cores
  • an Administrative Core
  • a Developmental Research Program
  • a Career Development Program

The Hillman Lung Cancer SPORE will use an interdisciplinary approach to meet its objectives by carrying out projects with co-investigators in basic, population, and clinical science. It is also organ-specific in its approach and all projects will test hypotheses about lung cancer biology, susceptibility, detection, prevention, or treatment.

The Hillman SPORE will carry out the directive to translate its findings within five years to human populations by using new knowledge to carry out interventions in humans and to determine the biological basis for observations made in patients with lung cancer or in individuals at high risk for lung cancer.

The long-term goal of the Hillman SPORE is to conduct clinical trials based on research results from its translational research projects that will serve as the basis for improving the outcome of patients diagnosed with lung cancer and to define new biological tools that will be useful in identifying asymptomatic lung cancer.

The four main Projects are:

  • Project 1: Bio-Marker Based Targeting of Estrogen Pathways in Lung Cancer
  • Project 2: Vitamin D and Chemoprevention of Lung Cancer
  • Project 3: Predicting Lung Cancer in the Pittsburgh Lung Screening Study
  • Project 4: Preclinical Assessment of Bioavailable and Orally Active ATR Kinase Inhibitors for the Treatment of Lung Cancer

The three Research Cores will assist the main research Projects, Developmental Research Projects, and Career Development Investigators in carrying out lung cancer translational research. The Research Cores are Clinical Core (Core B), Tissue and Blood Bank Core (Core C), and Biostatistics/Bioinformatics Core (Core D). The Administrative Core (Core A) will provide scientific and fiscal oversight for the program. Hillman SPORE investigators will work together as a team to meet the goals of the program and will also interact with investigators from other SPOREs and Cancer Centers, the NCI Program Office, and other co-operative groups to improve outcome for lung cancer patients.