Influences of the built environment on personal health behaviors have been well-documented, but what about influences from the information environment? Are we creating clarity of purpose in our communication to the general public on health-related topics, or are we merely contributing to confusion in what some have called the data smog of an online age? Have we made progress in realizing the behavioral objectives of cancer control through investments in online media, personalized decision support, and mobile access to information? If not, why not? This talk will draw on data from the NCIs Health Information National Trends Survey (HINTS) and from findings within the NCIs portfolio of research grants to address these, and similar, questions. Particular attention will be given to the role that the meaningful use requirements of the HITECH Act of 2009 are playing to empower health systems with a modernized, connected information environment for delivering better, safer, more patient-centered, and more equitable care. Although adoption of health information technologies has risen dramatically in the few years since the HITECH Act was passed, data suggest that public expectations may be outstripping systems capacities. Much remains to be done to ensure that the potential of the new environment will truly support the cognitive needs of clinical teams, patients, and caregivers. The talk will address the theoretical and empirical foundations upon which a new, user-friendly information environment can be built. New funding opportunities emerging from the collaboration of National Science Foundation and National Institutes of Health program leadership to create smart and connected health innovations to address these concerns will be highlighted. The goal, ultimately, is to create a more intelligent information environment to support the goals of cancer control along with other health interventions.