Lei Quan, PhD
Department of Cancer Prevention and Control
Roswell Park Cancer Institute
Buffalo, NY Disparities in breast cancer biology are evident between women of European Ancestry (EA) and women of African Ancestry (AA). Although breast cancer incidence is higher among EA women, AA women are more likely to have early aggressive breast cancer that cannot be treated with anti-estrogen therapy and often result in poorer clinical outcomes. There are few explanations for these differences by ancestry groups despite their importance in population-specific prevention or treatment of breast cancer. During this talk, Dr. Quan will explore the relationship between breast cancer disparity and genetic variants in two biologically relevant pathways, the adaptive immune response pathway and estrogen metabolism pathway, using data from the Womens Circle of Health Study (WCHS). Dr. Quan will also briefly present data on utilization of the mouse models to dissect various cancer-related quantitative traits such as susceptibility, regionality and tumor infiltration of lymphocytes.