UPMC Hillman Cancer Center

Michael Epperly, PhD

Michael Epperly
Associate Professor of Radiation Oncology


Contact Information

Contact Information

Department of Radiation Oncology
G.5 Hillman Cancer Center
5117 Centre Ave
Pittsburgh, PA 15213

Phone: 412-623-1014
Email: epperlymw@upmc.edu
Fax: 412-623-1010

Administrative Assistant
Name: Michael Lawton
Phone: 412-623-3214
Email: lawtonm@upmc.edu
Fax: 412-623-1010

Research Keywords

Research Keywords

Radiation oncology; manganese superoxide dismutase (MnSOD) radiation protection

Research Summary

Research Summary

Dr. Epperly's research focuses on the damaging effects of radiation on normal cells and tissues and the development of effective pharmacologic strategies to protect against and/or mitigate these effects.

Selected Publications

Selected Publications

  • Kalash R, Epperly MW, Goff J, Dixon T, Sprachman MM, Zhang X, Shields D, Cao S, Franciola D, Wipf P, Berhane H, Wang H, Au J, Greenberger JS. Amelioration of radiation-induced pulmonary fibrosis by a water-soluble bifunctional sulfoxide radiation mitigator (MMS350). Radiat Res. 2013 Nov;180(5):474-90. PubMed Link
    Shared Resources Used: AF, BF, IVIF
  • Lazo JS, Sharlow ER, Epperly MW, Lira A, Leimgruber S, Skoda EM, Wipf P, Greenberger JS. Pharmacological profiling of phosphoinositide-3-kinase inhibitors as mitigators of ionizing radiation-induced cell death. J Pharmacol Exp Ther. 2013 Dec;347(3):669-80. PubMed Link
    Shared Resources Used: AF
  • Berhane H, Epperly MW, Cao S, Goff JP, Franicola D, Wang H, Greenberger JS. Radioresistance of bone marrow stromal and hematopoietic progenitor cell lines derived from Nrf2 -/- homozygous deletion recombinant-negative mice. In Vivo. 2013 Sep-Oct;27(5):571-82. PubMed Link
    Shared Resources Used: AF, BF
  • Epperly MW, Chaillet JR, Kalash R, Shaffer B, Goff J, Franicola D, Zhang X, Dixon T, Houghton F, Wang H, Berhane H, Romero C, Kim JH, Greenberger JS. Conditional radioresistance of tet-inducible manganese superoxide dismutase bone marrow stromal cell lines. Radiat Res. 2013, 180(2):189-204. PubMed Link
    Shared Resources Used: AF, BF
  • Goff JP, Shields DS, Wang H, Skoda EM, Sprachman MM, Wipf P, Garapati VK, Atkinson J, London B, Lazo JS, Kagan V, Epperly MW, Greenberger JS. Evaluation of potential ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cells. Exp Hematol. 2013 Nov;41(11):957-66. PubMed Link
    Shared Resources Used: AF, BF
  • Frantz MC, Skoda EM, Sacher JR, Epperly MW, Goff JP, Greenberger JS, Wipf P. Synthesis of analogs of the radiation mitigator JP4-039 and visualization of bodipy derivatives in mitochondria. Org Biomol Chem. 2013, 11(25):4147-4153. PubMed Link
    Shared Resources Used: CTIF
  • Zellefrow CD, Sharlow ER, Epperly MW, Reese CE, Shun T, Lira A, Greenberger JS, and Lazo JS. Identification of druggable targets for radiation mitigation using a small interfering RNA screening assay. Radiat Res 2012 178(3):150-159. PubMed Link
    Shared Resources Used: AF
  • Samhan-Arias AK, Ji J, Demidova OM, Sparvero LJ, Feng W, Tyurin V, Tyurina YY, Epperly MW, Shvedova AA, Greenberger JS, Bayir H, Kagan VE, Amoscato AA. Oxidized phospholipids as biomarkers of tissue and cell damage with a focus on cardiolipin. Biochim Biophys Acta. 2012 1818(10):2413-2423. PubMed Link
    Shared Resources Used: AF
  • Stoyanovsky DA, Huang Z, Jiang J, Belikova NA, Tyurin V, Epperly MW, GreenbergerJS Bayir H and Kagan VE. A manganese-porphyrin complex decomposes H(2)0(2)inhibits apoptosis, and acts as a radiation mitigator in vivo. ACS Med Chem Lett. 2011, 2(11):814-817. PubMed Link
    Shared Resources Used: AF
  • Manni ML, Epperly MW, Han W, Blackwell TS, Duncan SR, Piganelli JD, Oury TD. Leukocyte-derived extracellular superoxide dismutase does not contribute to airspace EC-SOD after interstitial pulmonary injury. Am J Physiol Lung Cell Mol Physiol. 2012 301(1):L160-166. PubMed Link

See all pubs (Pubmed)

Collaborations

Collaborations

Current Internal Collaborators

Christopher Bakkenist, PhD
Associate Professor of Radiation Oncology
Member - Molecular and Cellular Cancer Biology Program (MCCBP)

Joel Greenberger, MD
Claude Worthington Benedum Foundation Professor of Radiation Oncology
Member - Lung Cancer Program (LCP)

Valerian Kagan, PhD, DSc
Professor of Environmental and Occupational Health
Member - Cancer Therapeutics Program (CTP)

Anthony Kanai, PhD
Associate Professor of Medicine

Peter Wipf, PhD
University Professor of Chemistry
Co-Leader - Cancer Therapeutics Program (CTP)

Shared Resource Usage

Shared Resource Usage

  • Animal Facility
  • Biostatistics Facility
  • Cell and Tissue Imaging Facility
  • Cytometry Facility
  • In Vivo Imaging Facility








Last modified: 9/20/16