UPMC Hillman Cancer Center

Joel S. Greenberger, MD

Joel Greenberger
Claude Worthington Benedum Foundation Professor and Chairman of Radiation Oncology


Contact Information

Contact Information

UPMC Shadyside Radiation Oncology
UPMC Cancer Pavilion, POB2, Rm. 533
5150 Centre Avenue
Pittsburgh, PA 15232

Phone: 412-647-3602
Email: greenbergerjs@upmc.edu
Fax: 412-647-6029

Administrative Assistant
Name: Susan Shimko
Phone: 412-647-3602
Email: shimkosp@upmc.edu
Fax: 412-647-6029

Research Keywords

Research Keywords

Radiation mitigator; radiation protection; lung cancer

Research Summary

Research Summary

Dr. Greenberger is examining the use of manganese superoxide dismutase (MnSOD) plasmid liposome gene therapy and GS-nitroxides, as agents to protect the normal tissues in the esophagus and lung from damage during radiation therapy. Damage to normal tissues during radiation therapy has been a major limitation to the effective treatment of lung cancer. The goal of his research is to improve the quality of life for cancer patients by potentially allowing the use of higher doses of radiation or chemotherapy to effectively treat lung cancer without the damaging side effects.

Selected Publications

Selected Publications

  • Epperly MW, Dixon T, Wang H, Schlesselman J, Franicola D, Greenberger JS. Modulation of total body irradiation induced life shortening by systemic intravenous MnSOD-plasmid liposome gene therapy. Radiat Res. 2008 Oct;170(4):437-43. PubMed Link
  • Epperly MW, Melendez JA, Zhang X, Nie S, Pearce L, Peterson J, Franicola D, Dixon T, Greenberger BA, Komanduri P, Wang H, Greenberger JS. Mitochondrial targeting of a catalase transgene product by plasmid liposomes increases radioresistance in vitro and in vivo. Radiat Res. 2009 May;171(5):588-95. PubMed Link
  • Goff JP, Shields DS, Seki M, Choi S, Epperly MW, Dixon T, Wang H, Bakkenist CJ, Dertinger SD, Torous DK, Wittschieben J, Wood RD, Greenberger JS. Loss of DNA polymerase theta (POLQ) causes radiosensitization of bone marrow stromal cells in vitro and alters hematopoietic response to irradiation in vivo. Radiat Res. 2009 Aug;172(2):165-74. PubMed Link
  • Jiang J, McDonald PR, Dixon TM, Franicola D, Zhang X, Nie S, Epperly LD, Huang Z, Kagan VE, Lazo JS, Epperly MW, Greenberger JS. Synthetic protection short interfering RNA screen reveals glyburide as a novel radioprotector. Radiat Res. 2009 Oct;172(4):414-22. PubMed Link
  • Jiang J, Stoyanovsky DA, Belikova NA, Tyurina YY, Zhao Q, Tungekar MA, Kapralova V, Huang Z, Mintz AH, Greenberger JS, Kagan VE. A mitochondria-targeted triphenylphosphonium-conjugated nitroxide functions as a radioprotector/mitigator. Radiat Res. 2009 Dec;172(6):706-17. PubMed Link
  • Niu Y, Wang H, Wiktor-Brown D, Rugo R, Shen H, Huq MS, Engelward B, Epperly M, Greenberger JS. Irradiated esophageal cells are protected from radiation-induced recombination by MnSOD gene therapy. Radiat Res. 2010 Apr;173(4):453-61. PubMed Link
  • Rajagopalan MS, Stone B, Rwigema JC, Salimi U, Epperly MW, Goff J, Franicola D, Dixon T, Cao S, Zhang X, Buchholz BM, Bauer AJ, Choi S, Bakkenist C, Wang H, Greenberger JS. Intraesophageal manganese superoxide dismutase-plasmid liposomes ameliorates novel total body and thoracic irradiation sensitivity of homologous deletion recombinant negative nitric oxide synthase-1 (NOS1-/-) mice. Radiat Res. 2010 Sep;174(3):297-312. PubMed Link
  • Tyurina YY, Tyurin VA, Kapralova VI, Wasserloos K, Mosher M, Epperly MW, Greenberger JS, Pitt BR, Kagan VE. Oxidative lipidomics of gamma-irradiation induced lung injury: Mass-spectrometric characterization of cardiolipin and phosphatidylserine peroxidation. Radiat Res. 2011 May;175(5):610-21. PubMed Link
  • Epperly MW, Wang H, Jones JA, Dixon T, Montesinos CA, Greenberger JS. Antioxidant-chemoprevention diet ameliorates late effects of total body irradiation and supplements radioprotection by MnSOD-plasmid liposome administration. Radiat Res. 2011 Jun;175(6):759-65. PubMed Link
  • Bernard ME, Kim H, Berhane H, Epperly MW, Franicola D, Zhang X, Houghton F, Shields D, Wang H, Bakkenist CJ, Frantz MC, Forbeck EM, Goff JP, Wipf P, Greenberger JS. GS-nitroxide (JP4-039) mediated radioprotection of human Fanconi Anemia cell lines. Radiat Res. 2011 Nov;176(5):603-12. PubMed Link

See all pubs (Pubmed)

Collaborations

Collaborations

Current Internal Collaborators

Hulya Bayir, MD
Professor of Critical Care Medicine

Valerian Kagan, PhD
Professor and Vice-Chairman of Environmental and Occupational Health
Member - Cancer Therapeutics Program (CTP)

Peter Wipf, PhD
Distinguished University Professor of Chemistry
Co-Leader - Cancer Therapeutics Program (CTP)

Shared Resource Usage

Shared Resource Usage

  • Animal Facility
  • Biostatistics Facility

Department Website









Last modified: 6/25/14