UPMC Hillman Cancer Center

David A. Clump, MD, PhD

David Clump
Assistant Professor of Radiation Oncology


Contact Information

Contact Information

UPMC Shadyside Hospital
Department of Radiation Oncology
5230 Centre Avenue, Posner Tower
Pittsburgh, PA 15232

Email: clumpda2@upmc.edu

Administrative Assistant
Name: Karen Holeva
Phone: 412-623-1275
Email: holevakd@upmc.edu
Fax: 412-623-4050

Research Keywords

Research Keywords

Head and neck cancer; squamous cell carcinoma; stereotactic radiosurgery; IMRT; DNA damage repair; normal tissue protection; ATM

Research Summary

Research Summary

Dr. Clump specializes in integrating his clinical practice, which focuses on the treatment of head and neck malignancies as well as stereotactic radiosurgery, with his translational laboratory interests. As part of UPCI and UPMC CancerCenter, Dr. Clump is uniquely positioned to investigate the effects of radiation on both tumor as well as normal tissues. In this regard, he studies the DNA damage response following radiation therapy and is examining the effects of these cellular changes on tumor control as well as systemic effects.

Selected Publications

Selected Publications

  • Vargo JA, Kubicek GJ, Ferris RL, Duvvuri U, Johnson J, DO JO, Clump DA, Burton S, and Heron DE. Adjuvant stereotactic body radiotherapy plus or minus cetuximab following salvage surgery in previously-irradiated head-and-neck cancer. Laryngoscope. 2014 Jul;124(7):1579-84. PubMed Link
  • Horne ZD, Clump DA, Vargo JA, Shah S, Beriwal S, Burton SA, Quinn AE, Schuchert MJ, Landreneau RJ, Christie NA, Luketich JD, and Heron DE. Pretreatment SUVmax predicts progression-free survival in early-stage non-small cell lung cancer treated with stereotactic body radiation therapy. Radiat Oncol. 2014 Jan 30;9:41. PubMed Link
  • Leeman JE, Heron DE, Clump DA, Flickinger JC, Mintz AH, and Burton SA. Extent of perilesional edema differentiates radionecrosis from tumor recurrence following stereotactic radiosurgery for brain metastases. Neuro Oncol. 2013 Dec;15(12):1732-8. PubMed Link
  • Bakkenist CJ, Crzambel RK, Clump DA, Greenberger JS, Beumer JH, and Schmitz JC. Radiation therapy induces the DNA damage response in peripheral blood. Oncotarget. 2013 Aug;4(8):1143-8. PubMed Link
  • Lim CM, Clump DA, Heron DE, and Ferris RL. Stereotactic body radiotherapy (SBRT) for primary and recurrent head and neck tumors. Oral Oncol. 2013 May;49(5):401-6. PubMed Link
  • Wang K, Heron DE, Clump DA, Flickinger JC, Kubicek GJ, Rwigema JC, Ferris RL, Ohr JP, Quinn AE, Ozhasoglu C, and Branstetter BF. Target delineation in stereotactic body radiation therapy for recurrent head and neck cancer: a retrospective analysis of the impact of margins and automated PET-CT segmentation. Radiother Oncol. 2013 Jan;106(1):90-5. PubMed Link
  • Leeman JE, Clump DA, Wegner RE, Heron DE, Burton SA, and Mintz AH. Prescription dose and fractionation predict improved survival after stereotactic radiotherapy for brainstem metastases. Radiat Oncol. 2012 Jul 11;7:107. PubMed Link
  • Greenberger JS, Clump DA, Kagan V, Bayir H, Lazo JS, Wipf P, Li S, Gao X, and Epperly ME. Strategies for discovery of small molecule radiation protectors and radiation mitigators. Front Oncol. 2012 Jan 13;1:59. PubMed Link

See all pubs (Pubmed)

Collaborations

Collaborations

Current Internal Collaborators

Christopher Bakkenist, PhD
Associate Professor of Radiation Oncology
Member - Molecular and Cellular Cancer Biology Program (MCCBP)

Robert Ferris, MD, PhD
Hillman Professor of Oncology and Professor of Otolaryngology, of Immunology, and of Radiation Oncology
Member - Head and Neck Cancer Program (HNCP)
Member - Cancer Immunology Program (CIP)

Dwight Heron, MD, FACRO, FACR
Professor and Chairman of Radiation Oncology
Member - Head and Neck Cancer Program (HNCP)

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Last modified: 7/13/17