UPMC Hillman Cancer Center

Carolyn Anderson, PhD

Carolyn Anderson
Co-Director, Hillman In Vivo Imaging Facility
Professor of Radiology
Professor of Chemical Biology and Pharmacology
Professor of Bioengineering

Contact Information

Contact Information

100 Technology Drive
Bridgeside Point Suite 452
Pittsburgh, PA 15219

Email: andersoncj@upmc.edu

Administrative Assistant
Name: Lynne Lewis
Phone: 412-624-6753
Email: lewisla@upmc.edu

Research Keywords

Research Keywords

Radiopharmaceuticals; metal radionuclides; diagnostic imaging; cancer imaging; radiotherapy; molecular imaging; positron emission tomography (PET); cancer metastasis

Research Summary

Research Summary


PET image of putative pre-metastatic sites in lungs with alpha 4 beta 1 targeting PET tracer, 64Cu-LLP2A.

The major focus of the Anderson Lab is the development, evaluation and application of radiopharmaceuticals containing metal radionuclides for diagnostic imaging and radiotherapy. We are particularly interested in 64Cu (T1/2 = 12.7 hours), in large part because it emits beta+ particles for positron emission tomography (PET) imaging and beta- particles for targeted radiotherapy. We are also investigating 68Ga (T1/2 = 68 min) as a generator-produced positron-emitting radionuclide. The agents we are studying are 64Cu- and 68Ga-labeled chelator-peptide and monoclonal antibody conjugates for imaging and/or therapy of various types of cancer. One area of investigation in our laboratory is the development of radiolabeled alpha vs. beta 3 integrin ligands as PET agents for imaging bone metastasis. We have developed one agent, 64Cu-CB-TE2A-c(RGDyK), that specifically binds to alpha vs. beta 3 integrin in osteoclasts, which are bone resorbing cells that are present in high concentration in osteolytic bone lesions. This agent may be able to earlier detect painful, debilitating bone lesions associated with breast cancer, and multiple myeloma, as well as be used to determine early response to treatment of bone lesions associated with these diseases. Another area of focus for our lab is investigating imaging agents that target cell types, other than tumor cells, involved in cancer metastasis. For example, we are targeting integrin alpha 4 beta 1 as a marker of bone marrow derived cells that home to sites of metastasis prior to tumor cells as part of the pre-metastatic niche. We are also investigating immune cell types, such as macrophages, neutrophils and T-cells and their role in cancer and other diseases.

Selected Publications

Selected Publications

  • Zeng D, Guo Y, White AG, Cai Z, Modi J, Ferdani R, Anderson CJ. Comparison of conjugation strategies of cross-bridged macrocyclic chelators with cetuximab for copper-64 radiolabeling and PET imaging of EGFR in colorectal tumor-bearing mice. Molecular Pharmaceutics, DOI 10.1021/mp500004m, 25 April 2014. PubMed Link
    Shared Resources Used: AF, IVIF
  • Zeng D, Zeglis BM, Lewis JS, Anderson CJ. The growing impact of bioorthogonal click chemistry on the development of radiopharmaceuticals. Journal of Nuclear Medicine, 2013; 54:829-832. PubMed Link
  • Cai Z, Ouyang Q, Zeng D, Nguyen KN, Modi J, Wang L, White AG, Rogers BE, Xie, X-Q, Anderson CJ. 64Cu-labeled somatostatin analogs conjugated with cross-bridged phosphonate-based chelators via strain-promoted click chemistry for PET imaging: in silico through in vivo studies. Journal of Medicinal Chemistry, 2014; DOI 10.1021/jm500416f, 7 July 2014 PubMed Link
    Shared Resources Used: AF, IVIF
  • Guo Y, Parry JJ, Laforest R, Rogers BE, Anderson CJ. The role of p53 on combination radioimmunotherapy with 64Cu-DOTA-cetuximab and cisplatin in a mouse model of colorectal cancer. Journal of Nuclear Medicine, 2013; 54:1621-1629. PubMed Link
  • Shokeen M, Pressly ED, Hagooly A, Zheleznyak A, Ramos N, Fiamengo AL, Welch MJ, Hawker CJ, Anderson CJ. Evaluation of multivalent, functional polymeric nanoparticles for imaging applications. ACS Nano, 2011; 5:738-747. PubMed Link

See all pubs (Pubmed)

Collaborations

Collaborations

Current Internal Collaborators

Robert Ferris, MD, PhD
Hillman Professor of Oncology and Professor of Otolaryngology, of Immunology, and of Radiation Oncology
Member - Cancer Immunology Program (CIP)
Member - Head and Neck Cancer Program (HNCP)

Michael Lotze, M.D.
Professor of Surgery
Member - Cancer Immunology Program (CIP)

Stephen Thorne, PhD
Assistant Professor of Surgery
Member - Cancer Virology Program (CVP)

Xiang-Qun Xie, PhD, MBA
Professor of Pharmaceutical Sciences/Drug Discovery Institute
Member - Cancer Therapeutics Program (CTP)

Current External Collaborators

Monica Shokeen, PhD
Instructor in Radiology
Washington University

Katherine Weilbaecher, MD
Associate Professor of Medicine
Washington University

Shared Resource Usage

Shared Resource Usage

  • Animal Facility
  • Biostatistics Facility
  • Cytometry Facility
  • In Vivo Imaging Facility

Affiliated Graduate Programs

Affiliated Graduate Programs

  • Bioengineering
  • Molecular Pharmacology

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Last modified: 7/13/17