UPMC Hillman Cancer Center

Warren Shlomchik, MD

Warren Shlomchik
Visiting Professor of Medicine


Contact Information

Contact Information

E1552 Thomas E. Starzl Biomedical Science Tower
Pittsburgh, PA 15261

Phone: 412-383-6960
Email: warrens@pitt.edu
Fax: 412-624-1172

Research Keywords

Research Keywords

Allogeneic hematopoietic stem cell transplantation; alloSCT; graft-versus-host disease; GVHD; graft-versus-leukemia; GVL; immune reconstitution; chronic myelogenous leukemia

Research Summary

Research Summary

Dr. Warren Shlomchik’s research program is dedicated to understanding the complex immunology of allogeneic hematopoietic stem cell transplantation (alloSCT), including graft-versus-host disease (GVHD), graft-versus-leukemia (GVL) and immune reconstitution. The overall goal of Dr. Shlomchik’s research is to make discoveries that can be translated in the clinic. One such discovery was that memory phenotype T cells induce less GVHD than do naive T cells, which has been tested in a phase I/II clinical trial wherein patients received grafts depleted of naive T cells. This approach is now being examined in a four-arm clinical trial that includes high and lower intensity conditioning and grafts that are matched related and unrelated. At the bench, Dr. Shlomchik has mostly taken genetic approaches with mouse models to test fundamental hypotheses regarding alloSCT immunology. One major part of his research program has focused on mechanisms of GVHD, including: 1) roles of donor and host antigen presenting cells in priming alloreactive T cells; 2) mechanisms of antigen presentation; and 3) roles of donor tissue infiltrating antigen presenting cells (APCs) in promoting GVHD end organ damage. The second main area of investigation has been in understanding mechanisms of GVL and GVL resistance. Dr. Shlomchik’s lab has developed mouse models of GVL-sensitive chronic phase CML (CP-CML) and GVL-resistant blast crisis CML (BC-CML), with both leukemias induced by retroviral transfer of human oncogenes. This has provided both realistic models and genetic flexibility in that leukemias can be induced in any mouse, including those that are gene-modified. Recently, his lab has been applying two-photon intravital microscopy to studies in both GVHD and GVL.

Selected Publications

Selected Publications

  • Mohammed J, Beura LK, Bobr A, Astry B, Chicoine B, Kashem SW, Welty NE, Igyarto BZ, Wijeyesinghe S, Thompson EA, Matte C, Bartholin L, Kaplan A, Sheppard D, Bridges AG, Shlomchik WD, Masopust D, Kaplan DH. Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-beta. Nat Immunol. 2016 Apr;17(4):414-21. PubMed Link
  • Bleakley M, Heimfeld S, Loeb KR, Jones LA, Chaney C, Seropian S, Gooley TA, Sommermeyer F, Riddell SR, Shlomchik WD. Outcomes of acute leukemia patients transplanted with naive T cell-depleted stem cell grafts. J Clin Invest. 2015 Jul 1;125(7):2677-89. PubMed Link
  • Camirand G, Wang Y, Lu Y, Wan YY, Lin Y, Deng S, Guz G, Perkins DL, Finn PW, Farber DL, Flavell RA, Shlomchik WD, Lakkis FG, Rudd CE, Rothstein DM. CD45 ligation expands Tregs by promoting interactions with DCs. J Clin Invest. 2014 Oct;124(10):4603-13. PubMed Link
  • Oberbarnscheidt MH, Zeng Q, Li Q, Dai H, Williams AL, Shlomchik WD, Rothstein DM, Lakkis FG. Non-self recognition by monocytes initiates allograft rejection. J Clin Invest. 2014 Aug;124(8):3579-89. PubMed Link
  • Walch JM, Zeng Q, Li Q, Oberbarnscheidt MH, Hoffman RA, Williams AL, Rothstein DM, Shlomchik WD, Kim JV, Camirand G, Lakkis FG. Cognate antigen directs CD8+ T cell migration to vascularized transplants. J Clin Invest. 2013 Jun;123(6):2663-71. PubMed Link
  • Reichenbach DK, Li Q, Hoffman RA, Williams AL, Shlomchik WD, Rothstein DM, Demetris AJ, Lakkis FG. Allograft outcomes in outbred mice. Am J Transplant. 2013 Mar;13(3):580-8. PubMed Link
  • MacDonald KP, Shlomchik WD, Reddy P. Biology of graft-versus-host responses: recent insights. Biol Blood Marrow Transplant. 2013 Jan;19(1 Suppl):S10-4. PubMed Link
  • Li H, Demetris AJ, McNiff J, Matte-Martone C, Tan HS, Rothstein DM, Lakkis FG, Shlomchik WD. Profound depletion of host conventional dendritic cells, plasmacytoid dendritic cells, and B cells does not prevent graft-versus-host disease induction. J Immunol. 2012 Apr 15;188(8):3804-11. PubMed Link
  • Zecher D, Li Q, Williams AL, Walters JT, Baddoura FK, Chalasani G, Rothstein DM, Shlomchik WD, Demetris AJ, Lakkis FG. Innate immunity alone is not sufficient for chronic rejection but predisposes healed allografts to T cell-mediated pathology. Transpl Immunol. 2012 Mar;26(2-3):113-8. PubMed Link
  • Wang X, Li H, Matte-Martone C, Cui W, Li N, Tan HS, Roopenian D, Shlomchik WD. Mechanisms of antigen presentation to T cells in murine graft-versus-host disease: cross-presentation and the appearance of cross-presentation. Blood. 2011 Dec 8;118(24):6426-37. PubMed Link

See all pubs (Pubmed)

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Last modified: 5/31/16