UPMC Hillman Cancer Center

David Bartlett, MD

David Bartlett
Bernard Fisher Professor of Surgery
Professor of Clinical and Translational Science
Vice Chairman, Surgical Oncology and Gastrointestinal Services
Director, David C. Koch Regional Perfusion Cancer Therapy Center

Contact Information

Contact Information

Hillman Cancer Center
5115 Centre Avenue
1.46 HCCLB
Pittsburgh, PA 15213

Phone: 412-623-7723
Email: bartlettdl@upmc.edu
Fax: 412-623-7709

Administrative Assistant
Name: Joan Czake
Phone: 412-692-2852
Email: czakejh@upmc.edu

Research Keywords

Research Keywords

Tumor selective oncolytic vaccinia viruses; immunotherapy; regional cancer therapies; HIPEC; peritoneal surface malignancies; translational research; peritoneal mesothelioma; therapeutic cancer vaccines

Research Summary

Research Summary

Although my overall group is very active in a wide range of clinical trials and translational/clinical research, my specialty is in the regional delivery of chemotherapy to manage regionally confined, unresectable metastatic cancers, and my laboratory-based program is in the development of oncolytic viruses for regional therapy. I have developed tumor selective oncolytic vaccinia viruses that have been tested in pre-clinical models and clinical trials and have a successful history of transitioning benchtop findings into clinical trial applications.

Selected Publications

Selected Publications

  • Guo ZS, Liu Z, Bartlett DL. Oncolytic immunotherapy: Dying the right way is a key to eliciting potent antitumor immunity. Front Oncol. 2014 Apr 10;4:74. PubMed Link
  • Magge D, Zenati MS, Austin F, Mavanur A, Sathaiah M, Ramalingam L, Jones H, Zureikat AH, Holtzman M, Ahrendt S, Pingpank J, Zeh HJ, Bartlett DL, Choudry HA. Malignant peritoneal mesothelioma: prognostic factors and oncologic outcome analysis. Ann Surg Oncol. 2014 Apr;21(4):1159-65. PubMed Link
  • Kang R, Zhang Q, Hou W, Yan Z, Chen R, Bonaroti J, Bansal P, Billiar TR, Tsung A, Wang Q, Bartlett DL, Whitcomb DC, Chang EB, Zhu X, Wang H, Lu B, Tracey KJ, Cao L, Fan XG, Lotze MT, Zeh HJ 3rd, Tang D. Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice. Gastroenterology. 2014 Apr;146(4):1097-107. PubMed Link
  • Yu F, Wang X, Guo ZS, Bartlett DL, Gottschalk SM, Song XT. T-cell engager-armed oncolytic vaccinia virus significantly enhances antitumor therapy. Mol Ther. 2014 Jan;22(1):102-11. PubMed Link
  • Kim SY, Song X, Zhang L, Bartlett DL, Lee YJ. Role of Bcl-xL/Beclin-1 in interplay between apoptosis and autophagy in oxaliplatin and bortezomib-induced cell death. Biochem Pharmacol. 2014 Mar 15;88(2):178-88. PubMed Link
  • Wong JL, Muthuswamy R, Bartlett DL, Kalinski P. IL-18-based combinatorial adjuvants promote the intranodal production of CCL19 by NK cells and dendritic cells of cancer patients. Oncoimmunology. 2013 Sep 1;2(9):e26245. PubMed Link
  • Bartlett DL, Liu Z, Sathaiah M, Ravindranathan R, Guo Z, He Y, Guo ZS. Oncolytic viruses as therapeutic cancer vaccines. Mol Cancer. 2013 Sep 11;12(1):103. PubMed Link

See all pubs (Pubmed)

Collaborations

Collaborations

Current Internal Collaborators

M. Haroon Choudry, MD
Assistant Professor of Surgery

Andrea Gambotto, MD
Associate Professor of Surgery
Member - Cancer Virology Program (CVP)

Zong Sheng Guo, PhD
Assistant Professor of Surgery

Yong Lee, PhD
Professor of Surgery
Member - Molecular and Cellular Cancer Biology Program (MCCBP)

Stephen Thorne, PhD
Assistant Professor of Surgery
Member - Cancer Virology Program (CVP)

Herbert Zeh, MD
Associate Professor of Surgery
Member - Cancer Immunology Program (CIP)

Qiuhong Zhang, MD, PhD
Research Instructor of Surgery

Shared Resource Usage

Shared Resource Usage

  • Animal Facility
  • Biostatistics Facility
  • Cancer Bioinformatics Services
  • Cancer Genomics Facility
  • Cancer Pharmacokinetics and Pharmacodynamics Facility
  • Cancer Proteomics Facility
  • Cell and Tissue Imaging Facility
  • Chemical Biology Facility
  • Cytometry Facility
  • IMCPL
  • In Vivo Imaging Facility
  • Investigational Drug Services
  • Tissue and Research Pathology Services

Affiliated Graduate Programs

Affiliated Graduate Programs

  • Clinical and Translational Science Institute

Department Website









Last modified: 7/13/17