UPMC Hillman Cancer Center

CCSG Acknowledgement

Required CCSG Acknowledgement

The NCI requires that publications acknowledge the Hillman CCSG support, and they are tracking compliance. If a Hillman CCSG-supported Shared Resource provided data used in your publication, please include the following statement in the acknowledgment section of your publication(s):

"This project used the Hillman [insert name(s) of shared resource(s)] that [is/are] supported in part by award P30CA047904."

Shared Resource Directors: Please make sure to include this statement on all of your order forms, contracts, etc. as a reminder to your users to acknowledge the Hillman CCSG support.

Services & Equipment

The Chemical Biology Facility (ChBF) provides Hillman members with expertise in in vitro, cell-based, and whole organism assay design, development, implementation, and lead characterization and optimization. Specific techniques available include protein-protein interactions, fluorescence polarization, time-resolved fluorescence resonance energy transfer, and nuclear translocation among other phenotypic and high content assays. Access to early safety assays is also available.

In addition to providing access to robust, sensitive, rapid, and cost-effective assays capable of screening a wide range of molecular targets against hundreds of thousands of existing and novel compounds, the ChBF provides guidance on designing and executing drug discovery and development projects from target and lead discovery through preclinical development. ChBF uses Quantitative Systems Pharmacology (QSP) as a major approach to drug discovery and development that combines computational and experimental methods to elucidate, validate, and apply new pharmacological concepts to the development and use of therapeutics.

Read more about ChBF facilities and equipment.