UPMC Hillman Cancer Center

Xin Huang, PhD

Xin Huang
Assistant Professor of Obstetrics, Gynecology & Reproductive Sciences

Contact Information

Contact Information

204 Craft Avenue
Pittsburgh, PA 15213

Phone: 412-641-6158
Email: huangx2@upmc.edu
Fax: 412-641-6156

Administrative Assistant
Name: Helen Gamrod
Phone: 412-641-6070
Email: hgamrod@upmc.edu
Fax: 412-641-6156

Research Keywords

Research Keywords

Ovarian cancer; tumor hypoxia; microRNA; miR-210; mitochondria; circulating biomarkers

Research Summary

Research Summary

Dr. Huang's laboratory is interested in studying the role of tumor hypoxia in ovarian cancer initiation and progression, particularly the function of a hypoxia-induced microRNA, miR-210. Because cellular energy metabolism is known to shift from oxidative phosphorylation to glycolysis under hypoxic conditions, one of our focuses is to study how miR-210 regulates mitochondrial function in rewiring cell metabolism in hypoxic tumor cells and how this change affects tumor behavior. In addition, HIF1a and HIF2a are the major transcription factors that regulate the cellular response to hypoxia. However, although they share many common target genes, they also regulate the expression of distinct set of genes. What determines the specificity of HIF1a or HIF2a targets is another area of interest of our group.

Ovarian cancer patients are usually diagnosed at late stages (stage III or IV), resulting in poor outcomes for most patients. Another major research focus in my lab is to identify circulating biomarkers for non-invasive detection of ovarian cancer at its earliest stage. If successful, these biomarkers hold great promise to dramatically improve the overall survival of ovarian cancer patients.

Selected Publications

Selected Publications

  • Huang X, Zuo J. Emerging roles of miR-210 and other non-coding RNAs in the hypoxic response. Acta Biochimica et Biophysica Sinica 2014, 46(3): 220-232. PubMed Link
  • Feng Y, Zhang S, Huang X. A robust TALENs system for highly efficient mammalian genome editing. Scientific Reports 2014, 4: 3632. PubMed Link
  • Ivan M, Huang X. miR-210: Fine-tuning the hypoxic response. Advances in Experimental Medicine and Biology 2014, 772: 205-227. PubMed Link
  • Suryawanshi S, Vlad AM, Lin HM, Mantia-Smaldone G, , Laskey R, Lee M, Lin Y, Donnellan N, Klein-Patel M, Lee T, Mansuria S, Elishaev E, Budiu R, Edwards RP, Huang X. Plasma microRNAs as novel biomarkers for endometriosis and endometriosis-associated ovarian cancer. Clinical Cancer Research 2013, 19(5): 1213-1224. PubMed Link
    Shared Resources Used: BF
  • Huang X, Le QT, Giaccia AJ. MiR-210 - micromanager of the hypoxia pathway. Trends Mol Med. 2010, 16(5):230-7. PubMed Link
  • Huang X, Ding L, Bennewith KL, Tong RT, Welford SM, Ang KK, Story M, Le QT, Giaccia AJ. Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell. 2009, 35(6):856-67. PubMed Link

See all pubs (Pubmed)

Collaborations

Collaborations

Current Internal Collaborators

George Tseng, ScD
Associate Professor of Biostatistics
Member - Molecular and Cellular Cancer Biology Program (MCCBP)

Nathan Yates, PhD
Associate Professor of Cell Biology
Member - Molecular and Cellular Cancer Biology Program (MCCBP)

Shared Resource Usage

Shared Resource Usage

  • Animal Facility
  • Biostatistics Facility
  • Cancer Proteomics Facility
  • Cell and Tissue Imaging Facility
  • In Vivo Imaging Facility

Department Website

Lab Website









Last modified: 10/21/14