UPMC Hillman Cancer Center

Steffi Oesterreich, PhD

Steffi Oesterreich
Professor of Pharmacology & Chemical Biology
Director of Education, Women's Cancer Research Center, UPCI

Contact Information

Contact Information

B411 Magee-Womens Research Institute
204 Craft Avenue
Pittsburgh, PA 15213

Email: oesterreichs@upmc.edu

Administrative Assistant
Name: Maria Harper
Phone: 412-641-7724
Email: harperm2@mail.magee.edu

Research Keywords

Research Keywords

Breast cancer; ovarian cancer; estrogen receptor; invasive lobular carcinoma; epigenetics; chromatin; coregulators; bone metastases; lobular carcinoma in situ; mutations

Research Summary

Research Summary

The main interest of Dr. Oesterreich’s laboratory is to further our understanding of hormone action in women’s cancers (including both breast and ovarian cancers), with the ultimate goal to use this knowledge for improved diagnosis and endocrine treatment. These studies include many aspects of translational breast cancer research utilizing basic biochemistry, molecular and cell biology, and cell lines, mouse models and clinical samples. Over the last few years, Dr. Oesterreich has developed a strong research interest in in situ and invasive lobular disease, the second most common yet understudied histological subtype of breast cancer. In her role as Director of Education at the Women's Cancer Research Center, Dr. Oesterreich is also very interested in providing outstanding training opportunities to the next generation of women's cancer researchers.

Selected Publications

Selected Publications

  • Sikora, MJ, Cooper KL, Bahreini A, Luthra S, Wang G, Chandran UR, Davidson NE, Dabbs DJ, Welm AL, Oesterreich S. Invasive lobular carcinoma cell lines are characterized by unique estrogen-mediated gene expression patterns and altered tamoxifen response. Cancer Res. 2014 Mar 1; 74(5):1463-74. PubMed Link
    Shared Resources Used: BF, CBS, TARPS
  • Pathiraja TN, Nayak S, Xi Y, Jiang S, Garee JP, Edwards DP, Lee AV, Chen J, Shea MJ, Santen RJ, Gannon F, Kangaspeska S, Jelinek J, Issa JJ, Richer JK, Elias A, McIlroy M, Young L, Davidson NE, Schiff R, Li W, Oesterreich S. Epigenetic reprogramming of HOXC10 in endocrine-resistant breast cancer. Science Transl Med 2014 Mar 26; 6(229):229. PubMed Link
    Shared Resources Used: BF, TARPS
  • Oesterreich S, Brufsky AM, Davidson NE. Using mice to treat (wo)men: mining genetic changes in patient xenografts to attack breast cancer. Cell Rep 2013 Sep 26; 4(6):1061-2. PubMed Link
  • Vasilatos SN, Katz TA, Oesterreich S, Wan Y, Davidson NE, Huang Y. Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells. Carcinogenesis 2013 34(6): 1196-207. PubMed Link
    Shared Resources Used: AF, BF
  • Oesterreich S, Davidson NE. The search for ESR1 mutations in breast cancer. Nat Genet. 2013 Dec; 45(12):1415-6. PubMed Link

See all pubs (Pubmed)

Shared Resource Usage

Shared Resource Usage

  • Animal Facility
  • Biostatistics Facility
  • Cancer Bioinformatics Services
  • Cancer Genomics Facility
  • Cancer Proteomics Facility
  • In Vivo Imaging Facility
  • Tissue and Research Pathology Services

Affiliated Graduate Programs

Affiliated Graduate Programs

  • Cellular and Molecular Pathology
  • Human Genetics
  • Molecular Pharmacology

Department Website

Lab Website









Last modified: 6/19/17