UPMC Hillman Cancer Center

Shilpa Sant, PhD

Shilpa Sant
Assistant Professor of Pharmaceutical Sciences


Contact Information

Contact Information

527 Salk Hall
3501 Terrace Street
Pittsburgh, PA 15261

Phone: 412-648-9804
Email: shs149@pitt.edu

Research Keywords

Research Keywords

Biomimetic microenvironments; tissue engineering; 3D tumor models; drug delivery

Research Summary

Research Summary

The goal of our laboratory is to develop an independent and multidisciplinary research program at the interface of biomaterials, controlled drug delivery, and tissue engineering. We use an interdisciplinary approach to build biomimetic microenvironments in vitro based on our expertise in the pharmaceutical sciences, materials sciences, cell biology and micro/nanotechnologies. Specifically, we aim to develop tissue-engineered tumor models that recreate the three-dimensional structure, cell-cell/cell-matrix interaction, stromal environments, and signalling cues present in vivo. These three-dimensional models will be used for understanding the pathophysiology of the disease as well as for preclinical evaluation of drug safety and efficacy.

Selected Publications

Selected Publications

  • Xue Y, Sant V, Phillippi J, Sant S. Biodegradable and biomimetic elastomeric scaffolds for tissue-engineered heart valves. Acta Biomater. 2017 Jan 15;48:2-19. PubMed Link
  • Singh M, Mukundan S, Jaramillo M, Oesterreich S, Sant S. Three-dimensional breast cancer models mimic hallmarks of size-induced tumor progression. Cancer Res. 2016 Jul 1;76(13):3732-43. PubMed Link
  • Patel A, Sant S. Hypoxic tumor microenvironment: Opportunities to develop targeted therapies. Biotechnol Adv. 2016 Sep-Oct;34(5):803-12. PubMed Link
  • Patel A, Xue Y, Mukundan S, Rohan LC, Sant V, Stolz DB, Sant S. Cell-instructive graphene-containing nanocomposites induce multinucleated myotube formation. Ann Biomed Eng. 2016 Jun;44(6):2036-48. PubMed Link
  • Patel A, Mukundan S, Wang W, Karumuri A, Sant V, Mukhopadhyay SM, Sant S. Carbon-based hierarchical scaffolds for myoblast differentiation: Synergy between nano-functionalization and alignment. Acta Biomater. 2016 Mar 1;32:77-88. PubMed Link
  • Singh M, Close DA, Mukundan S, Johnston PA, Sant S. Production of uniform 3D microtumors in hydrogel microwell arrays for measurement of viability, morphology, and signaling pathway activation. Assay Drug Dev Technol. 2015 Nov;13(9):570-83. PubMed Link
  • Liu H, Zhang Z, Seong Toh W, Ng KW, Sant S, Salgado A. Stem cells: Microenvironment, micro/nanotechnology, and application. Stem Cells Int. 2015;2015:398510. PubMed Link
  • Eslami M, Vrana NE, Zorlutuna P, Sant S, Jung S, Masoumi N, Khavari-Nejad RA, Javadi G, Khademhosseini A. Fiber-reinforced hydrogel scaffolds for heart valve tissue engineering. J Biomater Appl. 2014 Sep;29(3):399-410. PubMed Link
  • Goenka S, Sant V, Sant S. Graphene-based nanomaterials for drug delivery and tissue engineering. J Control Release. 2014 Jan 10;173:75-88. PubMed Link
  • Gaharwar AK, Mihaila SM, Swami A, Patel A, Sant S, Reis RL, Marques AP, Gomes ME, Khademhosseini A. Bioactive silicate nanoplatelets for osteogenic differentiation of human mesenchymal stem cells. Adv Mater. 2013 Jun 25;25(24):3329-36. PubMed Link

See all pubs (Pubmed)

Department Website

Lab Website









Last modified: 3/1/17