UPMC Hillman Cancer Center

Richard Steinman, MD, PhD

Richard Steinman
Associate Professor of Medicine, and Pharmacology & Chemical Biology

Contact Information

Contact Information

UPMC Cancer Pavilion
5150 Centre Avenue
Pittsburgh, PA 15232

Email: steinman@pitt.edu

Research Keywords

Research Keywords

Tumor microenvironment; melanoma; breast cancer; fibrosis

Research Summary

Research Summary


Engineered cells (red) cause cells that they touch to turn green. Goal is to control and trace cancer route in mice.

Dr. Steinman has interrogated the function and regulation of cdk inhibitors during quiescence and differentiation. His recent research focuses on dissection of the tumor microenvironment, including the development of a tool to enable topographically-restricted genetic manipulation of cells adjacent to cancer. Current questions under investigation include the contribution of fibrosis to metastatic growth and stromal factors that impact cancer dormancy and recurrence.

Selected Publications

Selected Publications

  • Steinman RA, Yang Q, Gasparetto M, Robinson LJ, Liu X, Lenzner DE, Hou J, Smith C, Wang Q. Deletion of the RNA-editing enzyme ADAR1 causes regression of established chronic myelogenous leukemia in mice. Int J Cancer. 2013 Apr 15;132(8):1741-50. PubMed Link
  • Steinman RA, Robinson AR, Feghali-Bostwick CA. Antifibrotic effects of roscovitine in normal and scleroderma fibroblasts. PLoS One. 2012;7(11):e48560. PubMed Link
  • Steinman RA, Brufsky AM, Oesterreich S. Zoledronic acid effectiveness against breast cancer metastases - a role for estrogen in the microenvironment? Breast Cancer Res. 2012 Sep 21;14(5):213. PubMed Link
  • Sharma R, Wang Y, Zhou P, Steinman RA, Wang Q. An essential role of RNA editing enzyme ADAR1 in mouse skin. J Dermatol Sci. 2011 Oct;64(1):70-2. PubMed Link
  • Andraos-Selim C, Modzelewski RA, Steinman RA. Inter-institutional development of a poster-based cancer biology learning tool. J Cancer Educ. 2010 Sep;25(3):413-7. PubMed Link
  • Ernst J, Ghanem L, Bar-Joseph Z, McNamara M, Brown J, Steinman RA. IL-3 and oncogenic Abl regulate the myeloblast transcriptome by altering mRNA stability. PLoS One. 2009 Oct 15;4(10):e7469. PubMed Link
  • Yasuoka H, Hsu E, Ruiz XD, Steinman RA, Choi AM, Feghali-Bostwick CA. The fibrotic phenotype induced by IGFBP-5 is regulated by MAPK activation and egr-1-dependent and -independent mechanisms. Am J Pathol. 2009 Aug;175(2):605-15. PubMed Link
  • Nichols M, Steinman RA. A recombinase-based palindrome generator capable of producing randomized shRNA libraries. J Biotechnol. 2009 Aug 20;143(2):79-84. PubMed Link
  • Steinman RA, Wentzel A, Lu Y, Stehle C, Grandis JR. Activation of Stat3 by cell confluence reveals negative regulation of Stat3 by cdk2. Oncogene. 2003 Jun 5;22(23):3608-15. PubMed Link
  • Steinman RA, Hoffman B, Iro A, Guillouf C, Liebermann DA, el-Houseini ME. Induction of p21 (WAF-1/CIP1) during differentiation. Oncogene. 1994 Nov;9(11):3389-96. PubMed Link

See all pubs (Pubmed)

Affiliated Graduate Programs

Affiliated Graduate Programs

  • Molecular Pharmacology

Department Website

Lab Website









Last modified: 11/7/14