UPMC Hillman Cancer Center

Partha Roy, PhD

Partha Roy
Associate Professor of Bioengineering and Pathology


Contact Information

Contact Information

306 CNBIO
300 Technology Drive
Pittsburgh, PA 15219

Phone: 412-624-7798
Email: par19@pitt.edu

Research Keywords

Research Keywords

Breast cancer; ovarian cancer; cell migration; tumor metastasis; angiogenesis; actin cytoskeleton; BRCA1

Research Summary

Research Summary

1) Directed cell migration plays an important role in embryonic development, wound healing, angiogenesis, immune response, cancer invasion and metastasis. Dynamic reorganization of actin cytoskeleton, a key aspect of cell migration, is regulated by the concerted actions of various classes of actin-binding proteins (ABPs), and some of these ABPs are fundamental drivers of actin-based cell motility. Altered expressions and activities of fundamental drivers of cell migration are correlated with aberrant cell motility in pathologic scenarios. Our main research interests are to: a) gain novel insights on how dysregulation of fundamental drivers of cell migration contributes to metastatic progression of solid cancers and pathological angiogenesis; and b) develop translational strategies exploiting the pathways of dysregulation as a means to suppress metastatic phenotype of cancer cells and angiogenesis-dependent pathology.

2) Post-translational modification plays a crucial role in regulating protein activities. We are exploring novel post-translational modifications of ABPs and how they impact protein function and actin-dependent biological processes.

3) Functional loss of expression of breast cancer 1, early onset gene (BRCA1) has been implicated in genomic instability and cancer progression. BRCA1 has been extensively studied in the context of DNA repair and cell cycle control. There is emerging evidence that BRCA1 can also play a role in cell migration and invasion. We are studying how BRCA1 regulates migration and metastatic propensity of ovarian cancer cells.

Selected Publications

Selected Publications

  • Ding Z, Joy M, Bhargava R, Gunsaulus M, Lakshman N, Miron-Mendoza M, Petroll M, Condeelis J, Wells A, Roy P. Profilin-1 downregulation has contrasting effects on early vs late steps of breast cancer metastasis. Oncogene. 2014 Apr 17;33(16):2065-74. PubMed Link
    Shared Resources Used: TARPS
  • Joy ME, Vollmer LL, Hulkower K, Stern AM, Peterson CK, Boltz RC, Roy P, Vogt A. A high-content, multiplexed screen in human breast cancer cells identifies profilin-1 inducers with anti-migratory activities. PLoS One. 2014 Feb 10;9(2):e88350. PubMed Link
  • Ding Z, Roy P. Profilin-1 versus profilin-2: two faces of the same coin? Breast Cancer Res. 2013 Jun 27;15(3):311. PubMed Link
  • Ding Z, Bae YH, Roy P. Molecular insights on context-specific role of profilin-1 in cell migration. Cell Adh Migr. 2012 Sep-Oct;6(5):442-9. PubMed Link
  • Bae YH, Ding Z, Das T, Wells A, Gertler F, Roy P. Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21547-52. PubMed Link
  • Zou L, Ding Z, Roy P. Profilin-1 overexpression inhibits proliferation of MDA-MB-231 breast cancer cells partly through p27kip1 upregulation. J Cell Physiol. 2010 Jun;223(3):623-9. PubMed Link
  • Bae YH, Ding Z, Zou L, Wells A, Gertler F, Roy P. Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins. J Cell Physiol. 2009 May;219(2):354-64. PubMed Link
  • Zou L, Hazan R, Roy P. Profilin-1 overexpression restores adherence junctions in MDA-MB-231 cells in R-cadherin dependent manner. Cell Motil Cytoskeleton. 2009 Dec;66(12):1048-56. PubMed Link
  • Das T, Bae YH, Wells A, Roy P. Profilin-1 overexpression upregulates PTEN and suppresses AKT activation in breast cancer cells. J Cell Physiol. 2009 Feb;218(2):436-43. PubMed Link
  • Zou L, Jaramillo M, Whaley D, Wells A, Panchapakesa V, Das T, Roy P. Profilin-1 is a negative regulator of mammary carcinoma aggressiveness. Br J Cancer. 2007 Nov 19;97(10):1361-71. PubMed Link

See all pubs (Pubmed)

Collaborations

Collaborations

Current Internal Collaborators

Adrian Lee, PhD
Pittsburgh Foundation Endowed Chair in Precision Medicine; Professor of Pharmacology & Chemical Biology
Co-Leader - Breast and Ovarian Cancer Program (BOCP)

Shivendra Singh, PhD
Professor of Pharmacology & Chemical Biology; UPMC Chair in Cancer Prevention Research
Member - Cancer Epidemiology and Prevention Program (CEPP)
Member - Breast and Ovarian Cancer Program (BOCP)

Andrew Stern, PhD
Research Associate Professor of Computational and Systems Biology

Andreas Vogt, PhD
Associate Professor of Computational and Systems Biology
Member - Cancer Therapeutics Program (CTP)

Alan Wells, MD, DMS
Thomas J. Gill III Professor of Pathology

Current External Collaborators

John Condeelis, PhD
Professor and Co-Chair of Anatomy & Structural Biology
Albert Einstein College of Medicine

Frank Gertler, PhD
Professor of Biology
Massachusetts Institute of Technology

Shared Resource Usage

Shared Resource Usage

  • Cancer Proteomics Facility
  • Tissue and Research Pathology Services

Affiliated Graduate Programs

Affiliated Graduate Programs

  • Bioengineering
  • Cancer Biology

Department Website









Last modified: 7/13/17