UPMC Hillman Cancer Center

Joseph Costantino, DrPH

Joseph Costantino
Professor of Biostatistics
Director of the NRG Oncology Statistics and Data Management Center


Contact Information

Contact Information

201 N. Craig Street
Suite 350
Pittsburgh, PA 15213

Email: costan@pitt.edu

Research Keywords

Research Keywords

Biostatistics; cancer clinical trials; breast cancer prevention and treatment; colorectal cancer prevention and treatment; breast cancer risk assessment; case/control studies

Research Summary

Research Summary

Dr. Costantino's primary research interest is the design, implementation and analysis of clinical trials, particularly those evaluating treatments for the prevention and control of cancer. Collaboration in the trials of the National Surgical Breast and Bowel Project and more recently the NRG Oncology Statistics and Data Management Center has been a major focus. The development of statistical methodologies for race-specific cancer risk assessment and the risk-benefit assessment of therapies associated with multiple endpoints of potential benefit and harm has evolved from this collaboration. A previous area of research focus involved the assessment of health effects from occupational and environmental exposures to airborne pollutants. This work dealt with the study and long-term follow-up of large occupational cohorts who were exposed to work-related airborne pollution. The thrust of this effort was to quantify health risks from pollution exposure and to evaluate methodologies to lower exposure and reduce the risks of diseases associated with exposure.

Selected Publications

Selected Publications

  • Land SR, Wichkerham DL, Costantino JP, Ganz PA. Cigarette smoking, physical activity, and alcohol consumption as predictors of cancer incidence among women at high risk of breast cancer in the NSABP P-1 trial. Cancer Epidemiol Biomarker Prev. 2014 Feb; 23 (5):823-32. PubMed Link
  • Cecchini RS, Costantino JP, Cauley JA, Cronin WM, Wickerham DL, Bandos H, Weissfeld JL, Wolmark N. Baseline mammographic breast density and the risk of invasive breast cancer in postmenopausal women participating in the NSABP study of tamoxifen and raloxifene (STAR). Cancer Prev Res (Phila). 2012 Nov; 5 (11):1321-9. PubMed Link
  • Cecchini RS, Costantino JP, Cauley JA, Cronin WM, Wickerham DL, Land SR, Weissfeld JL, Wolmark N. Body mass index and the risk for developing invasive breast cancer among high-risk women in NSABP P-1 and STAR breast cancer prevention trials. Cancer Prev Res (Phila). 2012 Apr; 5 (4):583-92. PubMed Link
  • Matsuno RK, Costantino JP, Ziegler RG, Anderson GL, Li H, Pee D, Gail MH. Projecting individualized absolute invasive breast cancer risk in Asian and Pacific Islander American women. J Natl Cancer Inst. 2011 Jun 22; 103 (12):951-61. PubMed Link
  • Vogel VG, Costantino JP, Wickerham DL, Cronin WM, Cecchini RS, Atkins JN, Bevers TB, Fehrenbacher L, Pajon ER, Wade JL 3rd, Robidoux A, Margolese RG, James J, Runowicz CD, Ganz PA, Reis SE, McCaskill-Stevens W, Ford LG, Jordan VC, Wolmark N, National Surgical Adjuvant Breast and Bowel Project. Update of the National Surgical Adjuvant Breast and Bowel Project Study of Tamoxifen and Raloxifene (STAR) P-2 Trial: Preventing breast cancer. Cancer Prev Res (Phila). 2010 Jun; 3 (6):696-706. PubMed Link
  • Shen Y, Costantino JP, Qin J. Tamoxifen chemoprevention treatment and time to first diagnosis of estrogen receptor-negative breast cancer. J Natl Cancer Inst. 2008 Oct 15; 100 (20):1448-53. PubMed Link
  • Gail MH, Costantino JP, Pee D, Bondy M, Newman L, Selvan M, Anderson GL, Malone KE, Marchbanks PA, McCaskill-Stevens W, Norman SA, Simon MS, Spirtas R, Ursin G, Bernstein L. Projecting individualized absolute invasive breast cancer risk in African American women. J Natl Cancer Inst. 2007 Dec 5; 99 (23):1782-92. PubMed Link
  • Costantino JP, Gail MH, Pee D, Anderson S, Redmond CK, Benichou J, Wieand HS. Validation studies for models projecting the risk of invasive and total breast cancer incidence. J Natl Cancer Inst. 1999 Sep 15; 91 (18):1541-8. PubMed Link
  • Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, Vogel V, Robidoux A, Dimitrov N, Atkins J, Daly M, Wieand S, Tan-Chiu E, Ford L, Wolmark N. Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst. 1998 Sep 16; 90 (18):1371-88. PubMed Link
  • Fisher ER, Costantino JP, Fisher B, Palekar SM, Suarez CM, Wolmark N. Pathologic findings from the National Surgical Adjuvant Breast Project (NSABP) Protocol B-17. Five-year observations concerning lobular carcinoma in situ. Cancer. 1996 Oct; 78 (7):1403-16. PubMed Link

See all pubs (Pubmed)

Collaborations

Collaborations

Current External Collaborators

John Blessing, PhD
Research Professor of Biostatistics
Roswell Park Cancer Institue

Walter Curran, MD
Lawrence W. Davis Professor and Chair of Radiation Oncology
Emory University

James Dignam, PhD
Associate Professor of Biostatistics
University of Chicago

Philip DiSaia, MD
Profesor of Obstetrics and Gynecology
University of California, Urvine

Norman Wolmark, MD
Professor and Chairman of Human Oncology
Drexel University

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Last modified: 12/13/16