UPMC Hillman Cancer Center

Aleksandar Rajkovic, MD, PhD

Aleksandar Rajkovic
Professor of Obstetrics, Gynecology & Reproductive Sciences
Division Chief, Genetics

Contact Information

Contact Information

Magee-Womens Research Institute, Rm A224
204 Craft Avenue
Pittsburgh, PA 15213

Phone: 412-641-7457
Email: rajkovica2@mail.magee.edu
Fax: 412-641-8519

Administrative Assistant
Name: Pauline Zorosak
Phone: 412-641-7531
Email: freep@upmc.edu
Fax: 412-641-6156

Research Keywords

Research Keywords

Ovarian failure; uterine fibroids; reproductive tract cancers; genetics

Research Summary

Research Summary

Our interests lie in basic and translational research in the area of reproductive genetics. We study reproductive tract pathologies in the context of developmental biology. We use both human studies and animal models to discover genes relevant to human pathologies. Our studies aim to reveal mechanisms of reproductive tract development as well as diagnostic and therapeutic targets for reproductive pathologies such as ovarian failure, uterine fibroids, and reproductive tract cancers.

Selected Publications

Selected Publications

  • Shin YH, McGuire M, Rajkovic A. HORMAD1 is a meiosis 1 checkpoint protein that modulates DNA double strand repair during female meiosis. Biol Reprod. 2013 Aug;89(2):29. PubMed Link
    Shared Resources Used: AF, CBS, CF, CTIF, IVIF, TARPS
  • Skaznik-Wikiel ME, McGuire MM, Sukhwani M, Donohue J, Chu T, Krivak TC, Rajkovic A, Orwig KE. Granulocyte colony-stimulating factor with or without stem cell factor extends time to premature ovarian insufficiency in female mice treated with alkylating chemotherapy. Fertil Steril. 2013 Jun;99(7):2045-54.e3. PubMed Link
    Shared Resources Used: AF, CBS, CF, CTIF, IVIF, TARPS
  • McGuire MM, Yatsenko A, Hoffner L, Jones M, Surti U, Rajkovic A. Whole exome sequencing in a random sample of North American women with leiomyomas identifies MED12 mutations in majority of uterine leiomyomas. PLoS One. 2012;7(3):e33251. PubMed Link
    Shared Resources Used: AF, CBS, CF, CTIF, IVIF, TARPS
  • Shin YH, Choi Y, Erdin SU, Yatsenko SA, Kloc M, Yang F, Wang PJ, Meistrich ML, Rajkovic A. Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis. PLoS Genet. 2010 Nov 4;6(11):e1001190. PubMed Link
    Shared Resources Used: AF, CBS, CF, CTIF, IVIF, TARPS

See all pubs (Pubmed)

Shared Resource Usage

Shared Resource Usage

  • Animal Facility
  • Cancer Bioinformatics Services
  • Cell and Tissue Imaging Facility
  • Cytometry Facility
  • In Vivo Imaging Facility
  • Tissue and Research Pathology Services

Affiliated Graduate Programs

Affiliated Graduate Programs

  • Cell Biology & Molecular Physiology
  • Human Genetics

Department Website

Lab Website









Last modified: 11/5/14